Temporal lobe epilepsy, corticobasal syndrome and mild cognitive impairment due to amyloid pathology
Clinical Case, 33 - 35Tag this article
Corticobasal syndrome can be characterized by an underlying Alzheimer’s disease pathology. We describe a patient who developed progressive asymmetric rigidity with limb apraxia, dystonia and alien limb phenomenon, preceded by lateonset temporal lobe epilepsy and followed by an amnestic mild cognitive decline. PET imaging with amyloid ligand showed diffuse cortical florbetaben retention. This case demonstrates the multiple phenotype associated to amyloid deposition, clinical comprising Alzheimer’s disease, corticobasal syndrome and late-onset temporal lobe epilepsy.
KEY WORDS: Corticobasal syndrome, amyloid pathology, florbetaben, temporal lobe epilepsy.