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Clinical Cases and Reviews in Epilepsy

Encephalopathy induced by levetiracetam in a young woman with normal renal function

Brief report/Clinical case, 25 - 27
doi: 10.11138/ccre/2016.1.1.025
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Abstract
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Levetiracetam (LEV) is an usually well-tolerated antiepileptic drug, effective in focal and generalized seizures. It has renal elimination and no hepatic metabolism. Commonly reported side effects are tiredness, sleep disturbances or psychiatric effects like aggression, anxiety and depression.
Cases of LEV-induced encephalopathy have been rarely reported and especially in patients with renal impairment (1) or when LEV was added to valproate (VPA) (2, 3). In these cases, patients developed psychomotor speed impairment and decreased level of consciousness, reflecting a diffuse slowing of the EEG. Following discontinuation of LEV, they showed a gradual improvement of the state of consciousness with normalization of EEG.
We describe a case of LEV-induced encephalopathy in a Caucasian woman with normal renal function, who received LEV in association with ethosuximide (ETS).

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