Cic edizioni internazionali
Clinical Cases and Reviews in Epilepsy

Psychiatric features in autosomal dominant lateral temporal epilepsy associated with LGI1 mutations

Brief report/Clinical Cases, 159 - 163
doi: 10.11138/ccre/2016.1.2.159
Tag this article
Abstract
Enhanced HTML Full text PDF
Objective: Mutations in the leucine-rich glioma-inactivated 1 (LGI1) gene or epitempin cause autosomal dominant lateral temporal epilepsy (ADLTE), an epileptic syndrome characterized by focal seizures with prominent auditory symptoms and benign clinical course. Psychiatric disorders have seldom been described in this condition.
This study aims to assess the psychiatric comorbidity in a small group of patients affected with ADLTE associated with LGI1 mutations.
Methods: We studied seven patients from three LGI1-mutated ADLTE families by means of psycodiagnostic scales, i.e. BDI (Beck Depression Inventory), STAI-Y (State-Trait Anxiety Inventory Y; 1 and 2), BIS-11 (Barratt Impulsiveness Scale-11), and TAS-20 (Toronto Alexithymia Scale-20). In addition, the Structured Clinical Interviews for DSMIV (SCID) for both Axis I (SCID-I) and Axis II (SCID II) disorders have been administered by specifical-
Clinical Cases and Reviews in Epilepsy 2016; 1(2):159-163 159 ly trained psychiatric interviewers.
Results: In our families, ADLTE patients display a high prevalence of psychiatric disorders, including both major disturbances and personality disorders according to the DSMIV. Moreover, higher levels of impulsiveness are observed in some ADLTE patients compared to healthy controls.
Discussion and conclusion: A small group of ADLTE-LGI1 mutated patients was shown to have high prevalence of psychiatric comorbidities and high levels of impulsiveness. These data need to be confirmed in a larger sample. A comprehensive psychiatric evaluation should be offered to these patients in order to define and treat these comorbidities.

Vol. 2 (No. 1) 2017 Janaury - December

  1. Post-stroke seizures: a clinical approach to diagnosis and treatment
    Brigo F., Bragazzi N.L., Nardone R.
    doi: 10.11138/ccre/2017.2.1.001
  2. Psychogenic non-epileptic seizures: an overview on terminology, epidemiology and diagnostic features
    Brigo F., Igwe S.C., Tezzon F., Nardone R.
    doi: 10.11138/ccre/2017.2.1.007
  3. Drug resistant epilepsy in a young male with Cat Eye Syndrome: a case study
    Verri A., Terzaghi M., Maffoni M., Caselli R., Recalcati M.P., Rognone E.
    doi: 10.11138/ccre/2017.2.1.015
  4. Stereotypy of psychogenic nonepileptic seizurelike events compared to temporal lobe seizures: a quantitative analysis of ictal events captured during Video EEG monitoring
    Vogrig A,, Hsiang J.C., Parvizi J.
    doi: 10.11138/ccre/2017.2.1.020
  5. Super-refractory status epilepticus or degenerative encephalopathy with rapid progression? A case report
    Pappalardo I., Cortellazzi P., de Curtis M., Didato G., Pastori C., Minardi I., Beretta S., Michelucci R., Villani F.
    doi: 10.11138/ccre/2017.2.1.027
  6. Polymicrogyria: the bigger the malformation, the worse the epilepsy, is that true?
    Mirandola L., Nobile G., Monti G., Giovannini G., Meletti S.
    doi: 10.11138/ccre/2017.2.1.033
  7. Is genetic aetiology an absolute contraindication for epilepsy surgery? Description of two patients with focal genetic epilepsy who underwent presurgical study
    Ferri L., Bisulli F., Mai R., Lichetta L., Leta C., Nobili L., Muccioli L., Mostacci B., Pippucci T., Tinuper P.
    doi: 10.11138/ccre/2017.2.1.037
  8. First clinical experiences with perampanel in adult patients with drug-resistant epilepsy and cognitive impairment
    Orlando B., Martino T., Quitadamo S.G., Di Claudio M.T., Lalla A., Avolio C., d'Orsi G.
    doi: 10.11138/ccre/2017.2.1.043
  9. Surgical indication and controversies in temporal lobe epilepsy of uncertain lateralisation associated with a unilateral glioneuronal lesion: report of two cases
    Marino D., Tumminelli G., Rocchi R., Bocci S., Pucci B., Sestini S., Cacciola F., Vatti G.
    doi: 10.11138/ccre/2017.2.1.049
  10. Epileptic phenotypes related to the UNC79-UNC80-NALCN protein complex
    Cossu S., Angius A., Oppo M., Onano S., Persico I., Persico I., Uva P., Cuccuru G., Asunis M., Crisponi L., Pruna D.
    doi: 10.11138/ccre/2017.2.1.054
  11. Axial propriospinal myoclonus misdiagnosed as myoclonic seizures
    Pascarella M.G., Martino T., Di Claudio M.T., Avolio C., d'Orsi G.
    doi: 10.11138/ccre/2017.2.1.059
  12. Atypical focal ESES/CSWSS: a clinical case
    Fatuzzo D., Giuliano L., Mainieri G., Lingenti V., Sofia V.
    doi: 10.11138/ccre/2017.2.1.062
  13. A novel de novo SCN8A mutation in an Italian child treated with Levetiracetam: a case in discussion
    Galati C., Isgrò A.R., Lo Re E., Calabrò N., Sgro D.L., Spanò M., Gagliano A.
    doi: 10.11138/ccre/2017.2.1.066
  14. Transauricular Vagus Nerve Stimulation (t-VNS) as a valid predictor of invasive VNS efficacy in drug resistant epilepsy: a case-report
    Barbella G., Freri E., Marotta G., Di Franesco J.C., Ferrarese C., Casazza M
    doi: 10.11138/ccre/2017.2.1.074
  15. Super-refractory status epilepticus in children: what happens when anesthetic therapy is not enough?
    Caputo D., Stoppa F., Vigevano F., Fusco L.
    doi: 10.11138/ccre/2017.2.1.080
  16. Ictal lateralized periodic discharges presenting as epilepsia partialis continua in a patient with chronic stroke
    Colombo M., Beretta S., Bogliun G., Ferrarese C.
    doi: 10.11138/ccre/2017.2.1.088
  17. Fixation-off sensitivity in a girl with symptomatic occipital epilepsy admitted in non-convulsive status epilepticus
    Puentes N.A., Menéndez A.G., Pérez Gil O., García Gutiérrez P.
    doi: 10.11138/ccre/2017.2.1.091
Last Viewed articles: la lista degli ultimi x visitati.
  1. Psychiatric features in autosomal dominant lateral temporal epilepsy associated with LGI1 mutations
    Santulli L., Caccavale C., Errichiello L., Striano P., de Falco F.A., de Falco A., Nobile C., Striano S.
    doi: 10.11138/ccre/2016.1.2.159
credits