Cic edizioni internazionali
Clinical Cases and Reviews in Epilepsy


Instructions for Authors
Clinical Cases and Reviews in Epilepsy" fields of clinical manifestations of epilepsy, but with all aspects of the diagnosis, natural history and management of seizure disorders including neurophysiological, imaging and other ancillary techniques. Submission is considered on the conditions that papers are previously unpublished, and are not offered simultaneously elsewhere; that all authors have read and approved the content, and all authors have also declared all competing interests; and th Policies of the journal, and has been conducted under internationally accepted ethical standards after relevant ethical review. This journal employs a plagiarism detection system. By submitting your manuscript to this journal you accept that your manuscript may be screened for plagiarism against previously published works.

Editorial Policies and Procedures
The journal operates a stringent peer review process.
manuscript may be returned immediately without full review.
on technical merit of the work, but also on other factors such as the priority for publication and the relevance to the Journal's general readership. All papers are judged in relation to other submissions currently under consideration.

Human studies should have been approved by an ethics committee but in questionable matters the Editors reserve the right to reject kinds of association (such as consultancy, share ownership, or patent should be disclosed to the Editor in a covering letter at the time of submission. Such informati will be held in confidence.

Committee on Publication Ethics (COPE)
(COPE), adherence to the submission criteria stated above is considered essential for publication in Clinical Cases and Reviews in Epi
process to ensure this. If, at a later stage in the submission process or even after publication, a manuscript and/or authors are found to have disregarded these criteria, it is the duty of the report this to COPE. COPE may recommend that action be taken to inform the authors’ professional
regulatory body and/or institution of such a dereliction. The website for COPE may be accessed at:

Pre-acceptance English language editing service
Authors for whom English is a second language should have their manuscript professionally edited or edited by a fluent English speaker before submission. This service is aimed to:
• improve grammar, spelling, and punctuation;
• improve clarity and resolve any ambiguity caused by poor phrasing;
• improve word-choice and ensure that the tone of the language is appropriate for an academic journal. Please contact the Editorial Office if you would like to receive the economic details of such services.

Scientific contributions
1) Reviews
Authors are welcome to submit their papers. Reviews are divided into narrative/opinion papers,
expressing the authors' opinion or organizational matters - sometimes based on some kind of
literature search - and systematic reviews on interventions, epidemiology and diagnostics where the
guidelines below are to be followed:
a) Statement of type: systematic review with/without meta-analysis
b) A structured abstract (please refer to section below headed “Abstracts”)
c) Introduction:
• Background
• Aim
d) Methods:
• Study design and participants
• Systematic literature search
• Primary and secondary outcomes
• Data extraction
• Data synthesis (e.g. type of meta-analysis)
e) Results:
• Description of included and excluded studies (trials flow diagram)
• Quality assessment of included studies
• Primary and secondary outcomes
• Sensitivity analyses
f) Discussion:
• Including implications for practice and further research
g) References
h) Legends to illustrations
i) Tables and their legends Systematic reviews and meta-analyses should conform to the PRISMA Statement (, and a checklist and flow diagram
should be included in your submission.
There is no set word limit for reviews.
2) Brief reports/ Clinical cases
Clinical case descriptions. Usually describe one to three patients or a single family. The text is limited to 2000 words, a maximum of 3 tables and figures (total), one or more video sequences and up to 25 references. They include a non-structured abstract.
Clinical case discussions. Manuscripts consider the step-by-step process of clinical decision making. Information about a patient is presented to an expert clinician(s) in stages to simulate the way such information emerges during clinical practice. The clinician responds as new information is presented, sharing his or her reasoning with the reader. The text should not exceed 2500 words, and there should be no more than 25 references. The use of clinical illustrative materials, such as xray films, neurophysiological data and videos, is encouraged. They include a non-structured abstract.
3) Clinical vignettes
Are classic images of common medical conditions. Visual images are an important part of what we do and learn in medicine. This feature is intended to capture the sense of visual discovery and variety that physicians experience.
4) Clinical trials
Articles are evidence-based results of clinical trials relevant to practicing physicians, both primary care providers and specialists. These studies are scrutinized for the strength of the hypothesis, the rigor of the experimental design, the evaluation and interpretation of the data, and the clinical implications of the study. In addition, clinical trials are subjected to a separate statistical reviewer.
Articles detail the pharmacology and the use of specific drugs used to treat particular diseases.
Because the essence of Clinical Trials articles is the evolution of therapeutic intervention, the Journal expects that the Authors of such articles will not have financial associations with a company (or competitor) that makes a product discussed in the article. They require a structured abstract.
5) Perspectives/ Commentaries
Usually provide background/context and/or commentary/analysis concerning an article in the issue of the Journal in which they appear. They may include an illustration or table. They are nearly always solicited, although occasionally, unsolicited proposals may be considered.
Perspectives/Commentaries are limited to 1200 words, with up to 5 references
6) Book reviews
Are generally solicited. We are willing to consider proposals for book reviews, but please contact the editorial office before submitting a review.

Manuscript Submission Guidelines
1) Title Page
The title page should include the title of the manuscript, the names of the authors and their institutional affiliations. Include the name, address, telephone number, fax number, and email address of the author who will be receiving correspondence and proofs and the email addresses of all other authors.
2) Abstracts
Systematic reviews and clinical trials require structured abstracts (that should not exceed 250 words). A structured abstract should be organized as follows:
Classification of Evidence (applicable for studies of therapeutic interventions)
Brief reports/Clinical cases and narrative reviews require a non-structured abstract.
3) References
References should be cited in the text by number within square brackets and listed at the end of the paper in the order in which they appear in the text. All references must be complete and accurate. If necessary, cite unpublished or personal work in the text but do not include it in the
reference list. Where possible the DOI for the reference should be included at the end of the reference. Online citations should include date of access. Use Medline abbreviations for journal
names. They can be found at: References
should be listed in the following style:
Sjoholm A, Nystrom T. Inflammation and the etiology of type 2 diabetes. Diabetes Metab Res Rev 2006; 22(1): 4-10.
Boulton AJM, Cavanagh PR, Rayman G. The Foot in Diabetes 4th Edn. John Wiley & Sons: Chichester, 2006; 1- 449.
Meltzer PS, Kallioniemi A, Trent JM. Chromosome Alterations in Human Solid Tumors. In: Vogelstein B, Kinzler KW, editors. The Genetic Basis of Human Cancer. New York: McGraw-Hill; 2002:93-113.
4) Illustrations
Upload each figure as a separate file in either .tiff or .eps format, with the figure number and the top of the figure indicated. Compound figures e.g. 1a, b, c should be uploaded as one figure. Tints are not acceptable. Lettering must be of a reasonable size that would still be clearly legible upon reduction, and consistent within each figure and set of figures. Where a key to symbols is required, please include this in the artwork itself, not in the figure legend. All illustrations must be supplied at the correct resolution:
Black and white and colour photos - 300 dpi
Graphs, drawings, etc - 800 dpi preferred; 600 dpi minimum
Combinations of photos and drawings (black and white and colour) - 500 dpi
Tables should be part of the the main document and should be placed after the references. If the table is created in excel the file should be uploaded separately.
Please note that since this journal is published online-only, there are no charges for colour figures.
5) Videos
An original feature of Clinical Cases and Reviews in Epilepsy is the possibility to publish video sequences, to demonstrate what constitutes the essence of epileptic phenomena and clinical semiology. Video material may be submitted as additional files of any kind of manuscript or in the format of video-teaching courses.
Videos as manuscript supplemental data Submit videos as separate Supplemental Data with your original manuscript submission. Video material of patients should be brief, approximately three to five minutes is usually adequate. The video should be of a high quality and illustrate the important points described in the manuscript.
Whenever possible, it is recommended to insert short explanatory legends immediately preceding video sequences or insert voiceover. When the patient is presented during a seizure in a language other than English, the authors should provide either a translation or, preferably, insert subtitles on the master video sequence(s).
Each video sequence should be accompanied by a legend to be published in the manuscript. The legend is expected to provide a short description of what is illustrated (semiology and/or EEG abnormalities, etc.), including a list of key words that are available on the website of the journal, corresponding to the following categories: phenomenology (maximum three key words), localisation (maximum three words), epilepsy syndrome (one key word), and aetiology (one key word). The key words are used to facilitate the search of video data on the Journal website. It is therefore preferable to choose the corresponding key words from the list available on the journal website. New key words may be chosen, although these will be included at the discretion of the Editor-in-Chief.
The Editor-in-Chief and Associate Editors reserve the right to request additional video editing by the authors or for the journal to edit the video material prior to publication, including insertion of voiceover.
Video teaching courses
Video teaching material on semiology of epileptic seizures, electroclinical aspects of epilepsy syndromes, and neurosurgery techniques will be considered for publication. The structure should be conceived for educational purposes and the video material must be of high quality.
Video format Video sequences are preferably submitted in an electronic format. The preferred standard is PAL and material should be sent in a QUICK-TIME® compatible format (Macintosh or PC). In order to digitalise video material from analogue sources, note that the following parameters should be used:
PAL FULL SCEEN (768 x 576, PAL one quarter screen: 384 x 288, Image rate: 25/sec) and NTSC
FULL SCEEN (640 x 480, NTSC one quarter screen: 320 x 240, Image rate: 29.97/sec). If there is any problem in uploading video material, the Editorial Office should be contacted (
Privacy and permissions
Privacy rules prohibit sending signed consent forms to the Editors-in-Chief without permission of the patient to do so. Consequently, video sequences which include recognisable patients must be accompanied by a letter from the corresponding author stating that signed consent forms authorising publication have been obtained for all identifiable patients. It is the authors' responsibility to ensure that all patients have given informed consent. Manuscripts will not be reviewed until this signed authorisation is received. If video of deceased patients is to be shown, written permission is
necessary from the next of kin. Written parental consent is required for all material of persons under the age of 18 years. It is the responsibility of the authors to obtain any other consent and permission which may be required by the institution in which the recordings were made and to comply with any other local regulations concerning the release of patient material for publication.
Ethical considerations
It is the author's responsibility to ensure that any experimental investigations on human subjects have been performed following their informed consent and with the approval of the relevant ethics committee(s). It is the author's responsibility to ensure that all patients or other subjects included on video or other photographic media have given informed consent allowing publication of the material, with the understanding that it will not be used for any other purposes than medical

Manuscript Submission
“Clinical Cases and Reviews in Epilepsy” operates an online submission and peer review system that allows authors to submit articles and track their progress online. Please, submit your review at
Copyright and Permissions Papers become copyright on acceptance for publication. Authors of all manuscripts are required to license copyright in their paper to CIC Edizioni Internazionali s.r.l. Copyright licensing is a
condition of publication. Accepted papers will not be been licensed. A completed Exclusive Licence Form must be sent by email (as a scanned
attachment), fax or post to the Editorial Office:

“Clinical Cases and Reviews in Epilepsy”
CIC Edizioni Internazionali
Corso Trieste 42, 00198 Rome -
k.a. Marilena Cefa
phone +39 06 8412673
fax + 39 06 8412688

Authors must sign, scan and upload to the online system.

Post Acceptance
For accepted manuscripts the publisher will supply proofs to the submitting author prior to publication. This stage is to be used only to correct errors that may have been introduced during the production process. Prompt return of the corrected proofs, pre will minimise the risk of a delay to publication.

Authority and Responsibility
The intellectual content of the paper is the responsibility of the authors. The Editors and the Publisher accept no responsibility for opin made by the Editor and Publisher to avoid inaccurate and misleading data, they accept no liability whatsoever for the consequences of wrong information. The authors agree to keep the Editors and Publisher fully and effectually indemnified against any liability or claims that may arise out of publication.